description
CONTENT: Anastrozolee, 1mg (10 pills)
Anastrozole is a highly selective non-steroidal aromatase inhibitor that turns androstenedione into estrone and then into estradiol in peripheral tissues in postmenopausal women. The therapeutic effect in patients with breast cancer is achieved by reducing the level of circulating estradiol. In postmenopausal women, anastrozole at a daily dose of 1 mg causes an 80% decrease in estradiol levels.
Has no progestin androgenic and estrogenic activity. The daily dose of up to 10 mg does not affect the secretion of cortisol and Aldosteron. No replacement for corticosteroids is required. Anastrozole may decrease the levels of hormone-positive early breast cancer in postmenopausal women Bone mineral densitycause.
Instructions for use
Adjuvant therapy for early Hormone positive Breast cancer in postmenopausal women. Frequent Breast cancer in postmenopausal women.
Adjuvant therapy for early hormone-positive breast cancer in postmenopausal women after tamoxifen therapy for 2-3 years.
side effect
From the side of the Vascular system : very often - tides.
From the musculoskeletal system: very often - arthralgia, joint stiffness, arthritis; Often - pain in the bones; Rarely - a trigger.
On the side of the reproductive system: often - dryness of the mucous membrane of the vagina, vaginal bleeding (especially during the first weeks after reversing or changing the previous hormonal therapy for anastrozole).
From the side of the furrow and dermal appendage: very often a rash; Often - alopecia, allergic reactions; Rarely - hives; Rare - Erythema Multiforme, Anaphylactoid reaction, skin vasculitis (including isolated cases of purpura (Shenlaine-Genoch syndrome)); Very rare - Stevens-Johnson syndrome, angioedema.
From the side of digestion: very often - nausea; Often - diarrhea, vomiting.
From the hepatobiliary system: often - increased activity of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase; Rare - increased Gamma-glutamyltransferase activity and bilirubin concentration, hepatitis.
From the nervous system: very often - headache; Often - drowsiness, carpal tunnel syndrome (observed mainly in patients with risk factors of the disease).
Of the page of Metabolism: often - anorexia, hypercholesterolemia. Approval of the drug may cause a decrease in bone mineral density due to a decrease in the concentration of the circulating Estradiols, which increase the risk of osteoporosis and fractures.
Others: very often - asthenia of mild to moderate severity.
Contraindications
Hypersensitivity to anastrozole or other components of the drug; Premenopause in women; Marked renal failure (creatinine clearance less than 20 ml / min); Moderate or severe liver dysfunction (safety and effectiveness not detected); Concomitant therapy with tamoxifen or estrogen hold Preparations. Pregnancy and lactation; Children's age (safety and efficacy not established in children).
Overdose
Cases of overdose are individual and random. A single dose of a drug the to life threatening Symptoms was not detected.
Treatment: There is none specific Antidote. Treatment is symptomatic. Induction of vomiting (if the patient is aware). Dialysis. General supportive therapy, patient monitoring and monitoring of function of vital Organs and systems.
