description
CONTENT: Tamoxifen 20, 20mg 10 pills
Antineoplastic antiestrogenic non-steroidal agent.
The mechanism of the anti-tumor effect is based on a competitive binding to estrogen receptors in target organs and an inhibition of the formation of the estrogen receptor complex with the endogenous ligand 17-r-estradiol.
dosage
The dosage regimen is set individually, depending on the indications, the condition of the patient and the antitumor therapy regimen used.
Side effects
On the part of the digestive system: nausea, vomiting, increased activity of liver transaminases; In some cases - fatty liver infiltration, cholestasis, hepatitis.
From the side of the central nervous system: rarely - depression, dizziness, headache, retrobulbar neuritis.
From the side of the organ of vision: rarely - retinopathy, keratopathy, cataract.
From the hemopoietic system: rarely - thrombocytopenia, leukopenia.
On the side of the endocrine system: in women - endometrial hyperplasia, vaginal bleeding, hot flashes, weight gain; In men - impotence, decreased libido.
From the cardiovascular system: edema, thromboembolism, phlebitis.
Dermatological reactions: alopecia, rash, itching.
Other: pain in bones and lesions, increase in body temperature.
type of application
Map inside as tablets. For breast cancer, take 20-40 mg 1-2 times a day; With endometrial cancer - 30-40 mg 1-2 times a day; With anovulatory infertility 10 mg 2 times a day for 4 consecutive days from the 2nd day of menstruation. For subsequent 4-day cycles, you can increase the dose to 20-40 mg 2 times a day.
Restrictions on use
Deep vein thrombosis and pulmonary embolism with a history of indirect anticoagulant treatment, coumarin series, thrombocytopenia, leukopenia, hypercalcemia, hyperlipidaemia, cataracts, or visual impairment.
