Text-Cypmax

Testosterone Cypionate is a white or creamy white crystalline powder, odorless or almost so and stable in the air. It is insoluble in water, freely soluble in alcohol, chloroform, dioxane, ether and soluble in vegetable oils.

Testo-Cypmax Maxtreme - Clinical Pharmacology

Endogenous androgens are responsible for the normal growth and development of the male reproductive organs and for the maintenance of secondary sexual characteristics. These effects include growth and maturation of the prostate, seminal vesicles, penis, and scrotum; Development of male hair distribution, such as beard, pubic, chest and axillary hair; Laryngeal enlargement, vocal cord thickening and changes in body muscles and fat distribution. Drugs in this class also cause nitrogen, sodium, potassium, and phosphorus retention and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. The nitrogen balance is only improved if there is sufficient intake of calories and protein.

Androgens are responsible for the growth spurt of adolescence and for the eventual cessation of the linear growth caused by the fusion of the epiphyseal growth centers.

In children, exogenous androgens accelerate linear growth rates, but can lead to disproportionate progress in bone maturation. Long-term use can lead to fusion of the epiphyseal growth centers and termination of the growth process. Androgens have been reported to stimulate red blood cell production by increasing the production of the erythropoietic stimulating factor.

During exogenous administration of androgens, endogenous testosterone release is inhibited by feedback inhibition of pituitary luteinizing hormone (LH). With large doses of exogenous androgens, spermatogenesis can also be suppressed by feedback inhibition of pituitary follicle stimulating hormone (FSH).

There is a lack of substantive evidence that androgens are effective in fractures, surgery, convalescence, and functional uterine bleeding.

Pharmacokinetics

Testosterone esters are less polar than free testosterone. Testosterone esters in oil that are injected intramuscularly are slowly absorbed from the lipid phase; Testosterone Cypionate can be given at intervals of two to four weeks.

Testosterone in plasma is 98 percent bound to a specific testosterone-estradiol-binding globulin and about 2 percent is free. In general, the amount of this sex hormone binding globulin in plasma determines the distribution of testosterone between free and bound forms, and the free testosterone concentration determines its half-life.

About 90 percent of a dose of testosterone is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites; About 6 percent of a dose is excreted in the feces, mostly in the unconjugated form. The inactivation of testosterone occurs primarily in the liver. Testo-Cypmax Maxtreme is metabolized to various 17-keto steroids by two different routes.

The half-life of testosterone cypionate when injected intramuscularly is around eight days.

In many tissues, the activity of testosterone appears to depend on its reduction to dihydrotestosterone, which binds to cytosolic receptor proteins. The steroid-receptor complex is transported to the cell nucleus, where it initiates transcription events and cellular changes related to androgen effects.

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